This is a very common genetic problem (1 in 400 to 1 in 1000 people) leading to the development of large kidneys, which are enlarged by the presence of cysts. These cysts can also develop in other organs, such as the liver and the pancreas. There is a variable expression of the problem within families, and not everybody with polycystic kidney disease will develop kidney failure - maybe 50-75% will progress. The genes responsible for this disease have been found. Often polycystic kidney disease will not cause anemia, as the kidneys still produce erythropoeitin. Polycystic kidney disease can cause pain, urinary infections, and blood in the urine.